In addition to developmental regulation, Sox8 plays an important role in the maintenance of tissue homeostasis (Fig. 2B), as evidenced by the phenotype of adult Sox8-deficient mice, which exhibit osteopenia, reduced weight, infertility, and poor recovery in demyelinating models (Freudenstein et al., 2023; Sock et al., 2001). Here, SOX8 is linked to Osteopenia.