7 Gu Gu HF HF Li Li N N Xu Xu ZQ ZQ Hu Hu L L Li Li H H Zhang Zhang RJ RJ et al et al Chronic Unpredictable Mild Stress Promotes Atherosclerosis Via HMGB1/TLR4-Mediated Downregulation of PPAR?/LXRa/ABCA1 in ApoE-/- Mice Chronic Unpredictable Mild Stress Promotes Atherosclerosis Via HMGB1/TLR4-Mediated Downregulation of PPAR?/LXRa/ABCA1 in ApoE-/- Mice Front Physiol Front Physiol 2019 2019 10 10 165 165 10.3389/fphys.2019.00165 10.3389/fphys.2019.00165. The gene discussed is APOE; the disease is atherosclerosis.