MBD2 and neurodegenerative disease: The main epigenetic modifications, including DNA methylation alterations, histone modifications, and dysregulated noncoding RNA modulation, have been implicated in a variety of degenerative diseases.[15] N6‐methyladenosine (m6A) is one of the most extensive RNA modifications and can be dynamically regulated by “writers” (methyltransferases), “erasers” (demethylases), and “readers”.[41] M6A has been shown to regulate the function and metabolism of circRNAs.[20, 42] However, little is known about the role of m6A modification in abnormal stress‐induced endplate cartilage degeneration.