YAP1 and Intervertebral disk degeneration: CEP calcification is considered one of the initial factors of intervertebral disc degeneration.[32] Our previous studies confirmed that the activation of osteoclast differentiation‐related pathways by Yap1 phosphorylation under abnormal stress is the main cause of endplate cartilage remodeling and degeneration.[8] However, abnormal stress directly leads to decreases in Yap1 mRNA and protein expression and the degeneration process of chondrocytes, which are not well understood.