Key proteins such as UTP18, UTP11, UTP3, NGDN, DNTTIP2, DDX49, NAT10, NOP14, RRP8, NOL8, HEATR1, NOL11, USP34, DCAF13, MAK16, IMP4, UTP6, USP36, MPHOSPH8, EXOSC2, and BAZ1B were identified as potentially relevant for HTR1B regulation in migraine. This evidence concerns the gene MAK16 and migraine disorder.