Key proteins such as UTP18, UTP11, UTP3, NGDN, DNTTIP2, DDX49, NAT10, NOP14, RRP8, NOL8, HEATR1, NOL11, USP34, DCAF13, MAK16, IMP4, UTP6, USP36, MPHOSPH8, EXOSC2, and BAZ1B were identified as potentially relevant for HTR1B regulation in migraine. The gene discussed is NGDN; the disease is migraine disorder.