Neuropathological associations with AD+P include increased neurofibrillary tangles (NFTs) and hyperphosphorylated tau burden in the brain (particularly in the prefrontal cortex), the presence of co‐morbid TAR DNA‐binding protein 43 (TDP‐43) pathology and higher total tau in cerebrospinal fluid (CSF).15, 16, 17, 18, 19, 20. Here, MAPT is linked to Alzheimer disease.