STAT6 and neoplasm: STAT6 demonstrated a moderate positive correlation with cytotoxic T-lymphocytes (CD8+) and M2-macrophages (CD163+), which reflects the involvement of this transcription factor in the regulation of not only adaptive immune reactions but also the modulation of the macrophage phenotype towards the M2-phenotype, which promotes immunosuppression and tumor growth (Chen et al., 2023).