This is consistent with previous studies indicating an important role of CD8+ T-cells in the antitumor response and regulating the immune microenvironment in various cancers, including thyroid cancer (Giles et al., 2023), although some studies highlighted the possible role of CD8+ in prognosticating TC recurrence (Cunha et al., 2015). The gene discussed is CD8A; the disease is thyroid gland carcinoma.