CD8A and thyroid gland papillary carcinoma: It is also important to note that CD8+ cells were the most numerous immune cells in TC, prevailing under B-cells and tumor-associated macrophages that can explain the relatively slow tumor progression, satisfactory prognosis and high survival rate of papillary thyroid cancer, the most common histological type of TC (Sheridan et al., 1995; Ulisse et al., 2021).