Based on the important roles of FOXC family (51), JUN (52, 53), and C/EBPβ (54) in glycolipid metabolism, we predicted that TNFRSF1A and SERPINB2 may play an important role in the pathogenesis of MAFLD and T2DM combined with MAFLD by regulating FOXC1, JUN, and C/EBPβ transcription factors. The gene discussed is SERPINB2; the disease is type 2 diabetes mellitus.