Recently, it has been observed in immortalized murine hypothalamic cells, both of embryonic and adult origin, that exposure to BPS, through GPER-1, induces the expression of the Agouti-related peptide (AgRP) gene, a neuropeptide crucial in the regulation of appetite and energy balance, which could contribute to metabolic disorders associated with obesity (124). This evidence concerns the gene GPER1 and metabolic disease.