The pathways were mainly enriched in lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, pathways in cancer, prostate cancer, kaposi sarcoma-associated herpesvirus infection, hepatitis B, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Chemical carcinogenesis - receptor activation, MAPK signaling pathway, toxoplasmosis, apoptosis, endocrine resistance, fluid shear stress and atherosclerosis, and TNF signaling pathway. The gene discussed is TNF; the disease is atherosclerosis.