Ponnian et al. evaluated the preventive effect of Vanillic acid (5 mg/kg, 10 mg/kg) on myocardial infarction rats induced by isoproterenol, and found that vanillic acid not only reduced the infarct size, but also downregulated the expression of bcl-2 and bcl-2 associated X (Bax) gene (Prince et al., 2011). The gene discussed is BAX; the disease is myocardial infarction.