VEGFA and endophthalmitis: Steroid injections increase the risk of endophthalmitis by 6.92 times (0.13% vs. 0.019%), possibly due to the larger bore needle used for steroids (27 or 25 G for triamcinolone and 22 G for DEX, compared to 30 or 32 G for anti-VEGF agents) and the immunosuppressive effects of steroids, which lower the threshold for bacterial infection [4].