Indeed, the fact that only a few tumor-promoting mutations have been reported so far, fusion proteins of YAP are more prevalent (Garcia et al., 2022) and YAP/TAZ tends to function as a hub to integrate extra-, inter- and intracellular oncogenic and tumorsuppressing signals, computational approaches will be particularly intriguing when developing novel therapeutics to modulate YAP/TAZ signaling. This evidence concerns the gene YAP1 and neoplasm.