Several groups described a link between EGFR signaling and the Hippo pathway in relation to the development of cancer, including in hepatocellular carcinoma (HCC) (Xia et al., 2018), lung cancer (Liang et al., 2024; Hsu et al., 2019) and breast cancer (Xu et al., 2024). This evidence concerns the gene EGFR and hepatocellular carcinoma.