Metastatic colorectal cancer xenograft (CT26) models; Deletion of Yap/Taz in endothelial cells using Yaplox/loxTazlox/lox mice crossed with Cdh5-(PAC)-CreERT2 mice (tamoxifen-inducible); Stat3 deletion using Stat3lox/lox crossed with Cdh5-(PAC)-CreERT2 mice. Here, STAT3 is linked to colorectal cancer.