For example, EGFR-dependent PI3K (phosphatidylinositol-3 kinase)-Akt signaling was discovered to serve as an upstream signal for the activation of YAP in the context of acute kidney injury (Chen et al., 2018) while ErbB2 drove YAP activation resulting in heart regeneration (Aharonov et al., 2020). The gene discussed is YAP1; the disease is acute kidney injury.