While our group has described a link between EGFR signaling and YAP involving Na,K-ATPase β2-subunit/AMOG (adhesion molecule on glia) and neurofibromin-2/Merlin in cerebellar granule cells (Litan et al., 2019), little is known about the interaction of EGFR and YAP in neurological diseases. The gene discussed is YAP1; the disease is nervous system disorder.