Another study showed a substantial change in the intracellular localization of YAP/TAZ proteins between soft and rigid matrices, with most cells showing predominant nuclear localization of YAP/TAZ on rigid matrices and a lesser number displaying distinct nuclear localization on soft matrices in idiopathic pulmonary fibrosis (Liu et al., 2015). This evidence concerns the gene YAP1 and idiopathic pulmonary fibrosis.