This was also seen in hepatocellular carcinoma where it was shown that EGFR mainly acts via PI3K-PDK1 signaling to activate and regulate YAP (Xia et al., 2018) whereas in glioblastoma, YAP nuclear translocation was regulated by EGFR through activation of the PTEN (phosphatase and tensin homolog)/Akt axis (Masliantsev et al., 2023). This evidence concerns the gene PTEN and glioblastoma.