Of note, results obtained from the murine HoxB8 model did not reveal any significant difference in the NE activity at any time post-infection with the wild-type strain W83, ∆KRAB, or stimulation with Porphyromonas gingivalis-isolated LPS, or in the presence of gingipain inhibitors KYT-1 and KYT-36 (Supplementary Figure S9). Here, HOXB8 is linked to infection.