Through PCR analysis of glycolysis-related genes (SLC2A1, SLC2A3, PKM, HK2, and ENO1) and oxidative phosphorylation (OCR) experiments to assess mitochondrial function, we verified the effect of vitamin A on mitochondrial metabolic reprogramming through STAT3 regulation under periodontitis conditions. The gene discussed is SLC2A1; the disease is periodontitis.