TNFSF10 and cancer: However, downregulated DEGs may be primarily regulated by some alternate mechanism than by upregulated DEmiRs in OC as molecular mechanisms and pathways associated with upregulated DEmiRs were distinct from those associated with downregulated DEGs, such as downregulation of TRAIL signaling and IFN-gamma pathway (Figure 7D) highlight immune evasion properties of OC, whereas downregulation of mesenchymal-to-epithelial transition (Figure 8D) hints to progression towards aggressive disease state, all contributing towards cancer progression in OC.