SMAD2 and Down syndrome: The top 10 key genes were tyrosine 3/tryptophan 5-monooxygenase-activating protein (YWHAZ), WTAP, VHL syndrome, vascular endothelial growth factor A (VEGFA), uncoordinated 51-like kinase 2 (ULK2), ubiquitin coupled enzyme 2N (UBE2N), tumor protein p53 (TP53), epidermal growth factor receptor (EGFR), SMAD homolog 2 (SMAD2), and tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) (Figure 9A).