TNF and psoriasis: TNF-α is the main cytokine regulator in inflammatory diseases, expressed after skin injuries (Banno et al., 2004) and associated with increased endothelial permeability and edema (Royall et al., 1989), while IL-6, which is known as a biomarker associated with severe Chikungunya fever (Ng et al., 2009), is also overexpressed in epidermal layers in cases of barrier disruption of the skin (Bonifati et al., 1994; Hänel et al., 2013), which is commonly observed in psoriasis patients (Johnson et al., 2020).