RAP2A and glioblastoma: ,130,131 CHI3L1 gene expression was notably elevated in GBM involving the SVZ, correlating with disease severity, increased invasion, immune infiltration, poor prognosis, and shortened survival.132, 133, 134 RAP2A-dependent actin cytoskeleton remodeling was found to inhibit the invasiveness of GBM accumulating in the SVZ.135