MYDGF and heart failure: Myeloid-derived growth factor is a paracrine protein produced by bone myeloid-derived monocytes and macrophages and is mainly expressed in Ly6Chigh monocytes, Ly6Clow monocytes, or mononuclear macrophages, T cells, B cells, endothelial cells, and cardiomyocytes.89, 90, 91 Employing RNA sequencing and functional verification, myeloid-derived growth factor promotes cardiomyocyte proliferation and cardiac regeneration in adult mice after MI by activating the c-Myc/Forkhead box M1 pathway, providing a potential target for reversing cardiac remodeling and heart failure.