,132 High expression of ADGRG1 also causes poor prognosis in patients with glioblastoma multiforme, acute myeloid leukemia, and osteosarcoma.133, 134, 135, 136 Notably, unlike other tumors, ADGRG1 is significantly down-regulated in highly metastatic human melanomas. This evidence concerns the gene ADGRG1 and acute myeloid leukemia.