Several genome-wide association studies based on ethnically diverse populations have found that the ADGRG6 single nucleotide polymorphism rs6570507 is significantly related to adolescent idiopathic scoliosis susceptibility.138, 139, 140, 141 Karner et al also confirmed that Adgrg6 is a genetic factor important for the etiology of adolescent idiopathic scoliosis and pectus excavatum.142. The gene discussed is ADGRG6; the disease is adolescent idiopathic scoliosis.