ADGRL3 and nervous system disorder: ,111 In contrast, single nucleotide polymorphisms associated with ADGRL3 are thought to increase susceptibility to attention deficit and hyperactivity disorder, autism spectrum disorder, and substance use disorder.112, 113, 114, 115 In addition to these neurological diseases, exome-wide association studies have found that genetic variation in ADGRL3 has a significant association with early-onset myocardial infarction and chronic kidney disease in Japanese individuals.116