To further investigate the crosstalk between IL-10 and IL-33, and whether IL-10’s effects on IgE-induced MC responses may depend on IL-33, we assessed the development of food allergy in WT and IL-10-depleted ST2-/- mice using an ovalbumin (OVA)-induced model of intestinal anaphylaxis. The gene discussed is IGHE; the disease is food allergy.