IL33 and food allergy: Food allergy induction in epicutaneously sensitized mice or mice with alterations in IL-4 signaling was attenuated in ST2-/- mice, suggesting that IL-33-mediated signals are critical for the development of oral anaphylaxis in mice, and that IL-33 promotes food anaphylaxis by targeting MCs or ILC2s (7, 8, 49–51, 80).