While some studies had suggested that IL-10 may induce suppression of IgE-mediated signaling in MCs (63, 64), more recently, several investigators including us, have shown that IL-10 can promote MC responses during food allergy (14), enhance STAT3 and miR-155-induced IgE-mediated activation (23), and promote MC expansion and activity during small bowel cancer (24). Here, STAT3 is linked to small intestine carcinoma.