NLRP3 and gout: Well-known for preserving cartilage integrity, recombinant human proteoglycan-4 exerts its anti-gout properties by restraining phagocytosis of MSU crystals, NF-κB nuclear translocation, and NLRP3 inflammasome activation in macrophages due to its interaction with CD44 (mainly) and TLR2/4 (partially) (63).