NLRP3 and gout: In the pathologic course of gout, a growing body of research evidence has revealed that MSU crystals as DAMPs first travel through lysosomes; afterward, the NLRP3 inflammasome forms a macromolecular conjugate to cleave procaspase-1 to caspase-1 and then promotes proteolytic initiation of IL-1β in macrophages; thus, gout is considered an NLRP3-dependent inflammatory disease.