S1P can up-regulate the expression of cell junction-related proteins such as E-cadherin and ZO-1 and promote VE-cadherin translocation, thereby strengthening the intestinal epithelial barrier and reducing the permeability of the intestinal epithelial layer, reducing sepsis-related intestinal injury, and improving the survival rate in sepsis (131, 132). The gene discussed is CDH5; the disease is Sepsis.