At present, FTY720 is regarded as a novel immunosuppressant with potent anticancer properties (78) In the MCA-RH7777 hepatocellular carcinoma cell line model, FTY720 reduced intrahepatic and pulmonary metastases as well as tumorigenesis, possibly through its function as an S1PR1 modulator (79). This evidence concerns the gene S1PR1 and hepatocellular carcinoma.