The pan-HDAC inhibitor panobinostat and the selective HDAC8 inhibitor PCI-34051 restored apoptosis induction by vemurafenib in resistant cells by suppressing S897-EphA2 and AKT signaling, and the combination of PCI-34051 with PLX4720 inhibited the growth of treatment-naïve 1205Lu melanoma xenografts [Table 2][94]. The gene discussed is HDAC8; the disease is melanoma.