HDAC inhibition by givinostat activated wildtype p53 in A375 BRAF-mutant melanoma cells, leading to apoptosis induction and reduction of BRAF expression, while BRAF-mutant SK-MEL-28 cells with mutant oncogenic p53 were less sensitive to givinostat-mediated apoptosis [Table 2 and Figure 3][83]. Here, TP53 is linked to melanoma.