As a crucial component of the Ras (rat sarcoma)-MAPK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated kinase) signaling pathway, which is strongly activated in numerous cancers, BRAF conveys activating signals from receptor tyrosine kinases (RTKs) and activated Ras to downstream MEK (MAPK/ERK) kinases and ERKs via phosphorylation[2]. This evidence concerns the gene BRAF and cancer.