Caspase-8-dependent apoptosis induction in BRAFV600E CRC by suppression of basal and selumetinib-induced expression of c-FLIPL, combination with selumetinib inhibits BRAFV600E HT-29 CRC xenograft growth via increased H4 acetylation and reduced STAT3 activation, apoptosis via caspase-3 activation. The gene discussed is STAT3; the disease is colorectal carcinoma.