These ferroptosis inducers specifically target engineered RAS mutant tumor cells via the RAS-BRAF (B-rapidly accelerated fibrosarcoma)-MAPK (mitogen activated protein kinase)/MEK (mitogen-activated protein kinase kinase)-MAPK/ERK (extracellular signal-regulated kinase) pathway and voltage-dependent anion channel (VDAC), inducing oxidative stress and mitochondrial dysfunction[1,36,37]. The gene discussed is WNK2; the disease is neoplasm.