Additionally, in melanoma, arachidonate 5-lipoxygenase induces autophagy-dependent ferroptosis via the AMPK/mammalian target of rapamycin (mTOR) pathway and downregulated GPX4[73], whereas calcium/calmodulin-dependent protein kinase kinase 2 protects cells against ferroptosis through the AMPK-NRF2 pathway[74]. Here, MTOR is linked to melanoma.