PIK3CA and colorectal cancer: Specifically, TIGAR contributes to ferroptosis resistance in colorectal cancer via the ROS/AMPK/SCD1 axis[71], while aspirin enhances RSL3-driven ferroptosis by inhibiting mTOR/SREBP-1 (sterol regulatory element-binding protein-1)/SCD1-regulated lipogenesis in PIK3CA-mutant colorectal cancer[117].