SREBF1 and hepatocellular carcinoma: Conversely, lactate-rich hepatocellular carcinoma cells show resistance to ferroptosis, where monocarboxylate transporter 1 (MCT1)-mediated lactate uptake inactivates AMPK and subsequently upregulates sterol regulatory element binding protein 1 (SREBP1) and SCD1, leading to increased production of anti-ferroptotic MUFAs[70].