For example, in colorectal cancer, p53 non-transcriptionally inhibits dipeptidyl peptidase 4 activity to prevent Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated lipid peroxidation and erastin-induced ferroptosis, whereas TP53 deficiency enhances this process[46,47]. The gene discussed is TP53; the disease is colorectal cancer.