Overexpression of miR-181c can inactivate the Hippo signaling pathway via directly targeting macrophage stimulating 1 (MST1), large tumor suppressor kinase 2 (LATS2), salvador family WW domain containing protein 1 (SAV1), and MOB kinase activator 1A (MOB1A), resulting in overactivation of yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) and promoting 5-FU chemoresistance in PC cells[68]. Here, SAV1 is linked to pachyonychia congenita.