EGFR and colorectal carcinoma: In another report, Wang et al. utilized GCD nanocarriers to co-deliver 5-FU and siRNA fragments (Anti-miRNA-10b) that could specifically inhibit miR-10b, effectively targeting CRC tumors with overexpressed EGFR, inhibiting the growth of CRC cancer cells and overcoming the problem of 5-FU resistance[141].