Overexpression of miR-4516 could downregulate the expression of its target gene inhibitor of growth family member 4 (ING4) and thereby enhance chemoresistance of GC cells through the elevation of Bcl-2 expression or the reduction of Bcl-2 associated X (BAX) and caspase-3 expression[75]. The gene discussed is ING4; the disease is gastric cancer.