Shu et al. disclosed that lncRNA LINC00680 could sponge miR-568 to accelerate the expression of AKT3 and activate its downstream signaling molecules such as mTOR, Eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 (EIF4EBP1), and p70S6K, which induces 5-FU resistance of HCC cells[96]. The gene discussed is EIF4E; the disease is hepatocellular carcinoma.