It was manifested that miR-196b-5p could instigate the STAT3 signaling pathway by targeting the suppressor of cytokine signaling 1 (SOCS1) and suppressor of cytokine signaling 3 (SOCS3), which are negative regulators of the STAT3 pathway in CRC cells, thereby enhancing chemoresistance to 5-FU[62]. The gene discussed is SOCS3; the disease is colorectal carcinoma.