Furthermore, Glypican-1 (GPC1) is specifically enriched in exosomes, and circulating exosomes with high GPC1 expression can be highly specific and sensitive when detected in the serum of PAAD patients, distinguishing between early-stage and late-stage patients with PAAD as well as healthy individuals with pancreatic diseases[70]. Here, GPC1 is linked to pancreatic adenocarcinoma.