SPARCL1 and Alzheimer disease: Here, we investigated the functional role of astrocytic Hevin in regulating cognitive decline in both pathological and normal brain aging using adeno‐associated virus to drive Hevin overexpression in hippocampal astrocytes of middle‐aged APP/PSEN mice, a well‐established animal model that recapitulates many pathological features of AD (Van Dam and De Deyn 2011).