To further characterize the molecular mechanisms underlying the effects of astrocytic Hevin overexpression in age‐mediated cognitive decline, we performed proteomic evaluation of the hippocampus from APP/PSEN and WT animals treated with AAV‐GFAP‐Hevin or AAV‐GFAP‐Mock for 6 months (Figure 5A, Data S1). Here, SPARCL1 is linked to Mental deterioration.