Compared with primary NK cells co-cultured with control primary HCC cells, we observed increased expression of activating receptors (NKp30, NKp46, and NKG2D) and CD69 on primary human NK cells co-cultured with 8d-pretreated primary HCC cells (Figures 5F–5I). This evidence concerns the gene KLRK1 and hepatocellular carcinoma.