,14,17,18 Interestingly, knockdown (KD) of BPTF in breast cancer cells leads to a reduction in heparanase (HPSE) expression, thereby compromising HPSE’s ability to cleave heparan sulfate proteoglycans (HSPGs), which serve as NCR ligands on the surface of tumor cells.12 The gene discussed is BPTF; the disease is breast cancer.