Among the top differential genes, genes associated with cell proliferation (FAT2, PCK1, SPDYC), ECM modulation (PODNL1, MMP10), and nervous system development (C1QL1, EN1) were upregulated in S100A2 cells, while genes associated with bacterial infection (IGJ) and apoptosis (CASP14, DIO3) were upregulated in MUC16 cells. The gene discussed is SPDYC; the disease is bacterial infectious disease.