Immunosuppressive states, such as those seen in HIV-infected individuals and transplant patients, disrupt cancer surveillance mechanisms.1,13 Human immunodeficiency virus not only enhances the activity of other oncogenic viruses, including HPV but also creates a state of chronic inflammation.1,13 Even in patients receiving ART with undetectable viral loads, C-reactive protein (CRP) and interleukin-6 (IL-6) levels remain elevated, contributing to an inflammatory environment promoting oncogenesis.13 The gene discussed is CRP; the disease is cancer.