The expression of PD‐1 was increased in DNT, CD4+ naive T cell, CD4+ Tem, CD8+ Tcm and CD8+ Tem cells in the tumour site, while the expression of CD39 was also up‐regulated in CD4+ Tcm, CD4+ Tem, CD4+ Treg and CD8+ Tem cells. The gene discussed is CD4; the disease is neoplasm.