Anti‐PD‐1 therapy systematically inhibited the expression of PD‐1 in T cells from samples including tumour, blood and bowel wall (Figures 7A and S9A,B) and significant down‐regulation of CD39 and CD69 in ILC and T cell subsets in TME was also observed (Figure S9C,D). This evidence concerns the gene CD69 and neoplasm.