CD4 and neoplasm: In the tumour–adjacent bowel wall, T cell subsets including CD4+ Tcm, CD4+ Treg, CD8+ Tem and B cell subsets composed of memory B cell, naïve B cell and MAIT cells were significantly increased in the lamina propria (Figure 7B), when naïve B cell and memory B cell were enriched in the muscularis propria (Figure 7C).