Moreover, the expression of CD69 in NKT and Lin− CD7+ cells from CMS4 tumours was remarkably higher than their counterparts in CMS1–3 tumours, while the expression levels of PD‐1 in CD4+ Tcm, CD4+ Tem, CD8+ Tcm, CD8+ Tem and CD8+ TEMRA from CMS4 tumours were significantly lower than their counterparts from other CMS groups (Figure 6D,E). This evidence concerns the gene CD4 and neoplasm.