As for tumour–adjacent bowel, CD4+ Treg cells were increased in lamina propria, when several T cell and B cell subtypes were increased in muscularis propria, such as CD4+ Tcm, CD4+ Tem, CD4+ Treg, CD8+ Tem, naïve B cell and memory B cells (Figure 3A,B). This evidence concerns the gene CD8A and neoplasm.