Several interactions only occurred in specific locations, such as signalling pathways of CALCR, RANKL and TWEAK in the submucosa, GDNF, GDF, IL12, CD30 and CD137 signalling pathways in the adenoma, and PD‐L1, GP1BA, RESISTIN and SPP1 signalling pathways in tumour. This evidence concerns the gene SPP1 and neoplasm.