Moreover, the expression level of CD39 was altered in several T cell subtypes from tumour–adjacent bowel, such as CD4+ Tem, CD8+ Tem, CD8− γδ T cells and especially CD4+ Treg, indicating that CD4+ Treg promoted the immune‐suppressive environment during tumour progression at the margin of tumour. This evidence concerns the gene ENTPD1 and neoplasm.