Likewise, exosomes from platelets in patients with multiple myeloma presented elevated levels of leucine-rich alpha-2-glycoprotein 1 (LRG1), which interacts with Olfactomedin 4 (OLFM4) in tumor cells, activating the EMT signaling pathway [108] (Fig. 1C). Here, LRG1 is linked to AL amyloidosis.