AQP4 and experimental autoimmune encephalomyelitis: In both cases, we used active immunization against the major I-Ab-restricted epitopes of MOG and AQP4, i.e. MOG(35–55) and AQP4(201–220), and analyzed the induced experimental autoimmune encephalomyelitis (EAE) clinically, by flow cytometry, and by immunohistochemistry to understand how antigen-specific T cells contribute to lesion localization in NMOSD.