IGHE and urticaria: Contact anaphylaxis represents the severe end of the spectrum of immunological contact urticaria and is thought to be a Type I hypersensitivity reaction, whereby antigens absorbed through the dermal barrier bind with specific IgE molecules on pre-sensitized mast cells, resulting in mast cell degranulation with the release of histamine and other vasoactive substances, such as prostaglandins, leukotrienes and kinins [1].