As proof of principle, we found that, in addition to its beneficial effects on models of stress and depression, the atypical antidepressant tianeptine rescues synaptic plasticity and cognitive deficits in a number of complementary HD animal models by promoting the diffusion trapping of AMPARs in a BDNF-TrkB-dependent manner [64]. The gene discussed is BDNF; the disease is major depressive disorder.