In comparison to isotype control IgE, the human IgE antibodies triggered significant RBL-SX38 cell degranulation in the presence of all three rHER2-expressing rat cancer cells (Fig. 3D) and mediated significant ADCC against these rat cancer cells by either RBL-SX38 cells or PBMCs (Fig. 3E, Supplementary Fig. 4A). The gene discussed is IGHE; the disease is cancer.