MOG and myeloid sarcoma: The role of B cells as APCs and T cells activator may be a key in MS pathogenesis; some studies demonstrated that mice with B cells that lacked MHC-II failed to present antigen to T cells, and did not develop EAE when stimulated with recombinant human myelin oligodendrocyte glycoprotein (rhMOG), with diminished Th1 and Th17 T cell responses [69].