B cells can contribute in MS pathogenesis through its pro-inflammatory mediator role as B cells can cause changes in the cytokine secretion pattern, increase in pro-inflammatory cytokines such as IL-6 [53], TNF-α, lymphotoxin-α (LT), and GM-CSF [54, 72], and a decrease in regulatory cytokines like IL-10, IL-35, and transforming growth factor-β (TGFβ) [73–75]. This evidence concerns the gene TNF and myeloid sarcoma.