CD4 and myeloid sarcoma: Several studies, on experimental autoimmune encephalitis model (EAE) [28], have proven the central role of CD4+‏ T lymphocytes in MS initiation and development; mainly CD4‏+ T helper 1 (Th1), T helper 17 (Th17) cells [29], and CD4+ Th2 cells are implicated in MS pathogenesis [30].