Using real-time PCR, Western blotting, and radioligand-binding assays, the mRNA and protein expression of GHRH-R, SV1 and immunoreactive GHRH have been observed in different human cancer cell lines and in human lung cancers, lymphomas, pancreatic cancers, glioblastomas, small-cell lung carcinomas, and in human nonmalignant prostate, liver, lung, kidney, and pituitary [12, 24, 28–31]. This evidence concerns the gene GHRHR and cancer.