miR-451a was previously reported to be implicated in inflammatory pathways via upregulating in rheumatoid arthritis and systemic lupus erythematosus (SLE) [33] and downregulating in influenza-infected dendritic cells which led to the increased secretion of inflammatory cytokines, e.g., IL6 and TNFα [34]. This evidence concerns the gene IL6 and systemic lupus erythematosus.