ZCCHC4 and neoplasm: Next, the relationship between ZCCHC4 levels and clinical pathological characteristics is explored, higher mRNA level of ZCCHC4 was significantly associated with lymph node metastasis statuses N0, N2, N3, and N4 (Fig. 1F), cancer stages 1–4 (Fig. 1G) and tumor histology (Fig. 1H).