In summary, the present study elucidates the overexpression of ZCCHC4 in esophageal cancer, with a marked correlation observed between ZCCHC4 mRNA levels and clinicopathological features, suggesting a potential adjunctive role for ZCCHC4 in the diagnosis and prognosis of esophageal cancer. The gene discussed is ZCCHC4; the disease is esophageal cancer.