ZCCHC4 and esophageal squamous cell carcinoma: When ZCCHC4 was depleted, the viability of ESCC cells was significantly inhibited (Fig. 4D), the sensitivity of ESCC cells to cisplatin has increased (Fig. 4E), cell cycle arrest in the G2 phase and a reduction in the S phase (Fig. 4F) and apoptosis was markedly increased (Fig. 4G).