Esophageal tumor markers (CEA, SCC, TPA, CYFRA21-1) emerge as multifaceted biomarkers, not merely confined to their role as auxiliary diagnostic aids in esophageal cancer but also intimately intertwined with the prognosis of patients, as evidenced by the dynamic fluctuations in their serum concentrations. This evidence concerns the gene SERPINB3 and neoplasm of esophagus.