In the adjuvant scenario, the multicentric PROQURE dose-escalation study aims to explore the combination of SoC external beam radiation therapy (EBRT, 7 weeks), ADT (3 years) plus a single cycle of 3, 6 or 9 GBq of [177Lu]Lu-PSMA-617 (2nd EBRT week) in 18 PSMA PET-positive N1M0 PCa. This evidence concerns the gene FOLH1 and posterior cortical atrophy.