However, a significant association between low TRIM8 mRNA expression and poor overall survival outcomes was predicted based on published data for cohorts of patients with lung adenocarcinoma (n = 672; P = 2E–6; Fig. 2F) and stage I disease (n = 346; P = 0.0029; Fig. 2G). The gene discussed is TRIM8; the disease is lung adenocarcinoma.