Under conditions that mimicked the TME (low glucose, glutamine, and pyruvate), the levels of MCT1, MCT4, cluster of differentiation 147 (CD147), peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) and other mRNAs were increased after 6 h of lactic acid treatment in parental pancreatic cancer cells expressing GPR81. Here, HCAR1 is linked to pancreatic neoplasm.