PKM and glioblastoma: Hearin, K673-pe exhibited a synergistic tumor-suppressive effect when combined with chemotherapy.243 D34-919 blocked the interaction between ALDH1A3 and PKM2 in GBM cells, thereby suppressing the downstream lactylation of XRCC1, which restored the sensitivity of GBM to TMZ-based chemotherapy and radiotherapy in GBM organoid models.244,436