TP53 and colorectal carcinoma: As a result, the tumor suppressor gene p53 was not lactylated at K120 and K139, which inhibited tumor progression in a CRC mouse model.239 Downregulation of pan-Kla writer KAT8 by the histone deacetylase (HDAC) inhibitor MG149 blocks the KAT8-eEF1A2 Kla axis and suppresses CRC tumor growth, particularly in a high-lactic TME.240