LDHA and thyroid gland papillary carcinoma: In addition, LDHA inhibition induced by oxamate led to the accumulation of ROS and depletion of cellular ATP, leading to DNA damage, DNA repair activity impairment and boosted radiotherapy efficiency in NSCLC.190 Moreover, LDHA inhibitor restores sensitivity towards radioiodine (RAI) in papillary thyroid cancer (PTC).