AARS1 and gastric cancer: AARS1 binds directly to lactate, catalyzes the adenosine triphosphate (ATP)-dependent synthesis of lactate-AMP and mediates widespread lysine lactylation, including that of p53.239 AARS1 was also uncovered to lactylate and activate the Yes-associated protein-TEA domain transcription factor (YAP-TEAD) complex in gastric cancer.