CPT2 and gastric cancer: As a Hippo target gene that creates a positive-feedback loop with YAP-TEAD complex, AARS1 promotes proliferation of gastric cancer.256,257 Additionally, alanyl-tRNA synthetase 2 (AARS2) has been shown to act as a mitochondrial lactyltransferase as well, catalyzing the lactylation of K336 in pyruvate dehydrogenase complex 1 (PDHA1) and K457/8 in carnitine palmitoyltransferase 2 (CPT2) under hypoxic conditions.