SLC16A1 and neoplasm: Isotopic tracing of xenografts in mice showed that MCT1-mediated lactate utilization, reflected by TCA metabolites, was elevated in tumors with high metastatic potential compared with tumors with low metastatic potential.16 Other articles have also emphasized this emerging perspective that glucose serves as a specific fuel while lactate as a universal fuel.159,160 In a word, these studies illustrate that lactate is by no means just a useless byproduct of rapid tumor energy consumption in anaerobic stress.