MTOR and pancreatic endocrine carcinoma: Metabolic symbiosis invigorates the metabolic potential of tumor tissues for anaerobic environments and facilitates tumor proliferation and metastasis.130,134,135 It happens in hypoxic regions of tumor regression and increases invasion and metastasis in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma (GBM).136 Studies unveiled that mTOR (mammalian target of rapamycin) mediated lactate shuttle induced by sunitinib/axitinib in PanNET, the inhibition of which significantly reduced tumor burden and viability.134