PDCD1 and melanoma: Regardless of its effect as a tumor suppressor, emerging evidence validates the role of LDH inhibitors as an immunotherapy sensitizer.390 Using oxamate and PD-1 blockade pembrolizumab stimulated CD8 + T cell infiltration and hindered tumor proliferation in humanized mouse NSCLC model, thereby sensitizing immunotherapy.391 In preclinical melanoma mouse model, LDHA inhibitor GSK2837808A increased therapeutic effect of adoptive T cell therapy (ACT).392 Likewise, LDH inhibitors contribute to photothermal therapy (PTT).