LDHA and cancer: This diverts metabolic precursors of pyruvate into the pentose phosphate pathway, which supports cancer cell proliferation.74,189,374,375 A high level of LDHA indicates poor prognosis in several human malignancies.189,376,377 Meanwhile, overexpression of LDHB has been found in plenty of different cancers, including breast, thyroid, lung, and pancreatic cancer, which is significantly associated with unfavorable prognosis.378–380 Current efforts are focused on development of LDH inhibitors with better cellular potency, PK properties, and selective compounds and remain in preclinical state.