PDK4 and uterine cervix neoplasm: In contrast, inhibiting pyruvate dehydrogenase kinase 4 (PDK4) mitigates lactate-induced DNA damage and curbs the SASP.184–187 In addition, Hu et al. confirmed that in 4T1 and HeLa cells, LDHA mediated hydrogen peroxide production under oxidative stimuli in vivo and in vitro.188 Concerning cervical tumor, nuclear LDHA acquired a non-canonical enzymatic activity to produce α-hydroxybutyrate (α-HB), which facilitated interaction between disruptor of telomeric silencing 1-like (DOT1L) and LDHA, which mediated hypermethylation of histone H3K79.