Li et al. revealed that in breast cancer mouse model, MCT inhibitor Syrosingopine downregulated the number of Treg cell and upregulated that of NK cells and M1 phenotype of TAM, suggesting reversal of the immunosuppressive TME.416 Meanwhile, Ma et al. found that in vivo and in vitro, Lithium carbonate (LC) assisted MCT1 localization to mitochondrial membranes and lactate influx into mitochondria. This evidence concerns the gene SLC16A1 and breast carcinoma.