TP53 and neoplasm: Regarding non-histone lactylation, other research also validated its effect on prompting tumor progression.235–238 Zong et al. uncovered that alanyl-tRNA synthetase 1 (AARS1) detected lactate and facilitated the site-specific lactylation of p53, which weakened its ability to bind DNA and underwent liquid-liquid phase separation (LLPS).