Inhibition of LDHA by oxamate significantly boosted radiosensitivity and enhanced apoptosis, autophagy and cell cycle turbulence triggered by ionizing radiation (IR) in A549 and H1975 cancer cells.190 Response to fractionated irradiation correlates with lactate concentration of tumor regions in 10 xenografted human HNSCC tumor lines.191 Besides, disturbances in oxidative homeostasis due to lactate are also associated with metastasis. The gene discussed is LDHA; the disease is neoplasm.