Across the HER2+ and cutaneous squamous cell carcinoma (cSCC) ST datasets, we measured the relative performance across all genes based on Pearson Correlation Coefficient (PCC), Mutual Information (MI), Structural Similarity Index (SSIM) and Area Under the Curve (AUC) (Table 2) for each method (Fig. 2d). The gene discussed is ERBB2; the disease is skin squamous cell carcinoma.