Mechanistically, IRE1α activation silences double-stranded RNA (dsRNA) released because of taxane-induced DNA damage through a process called IRE1-dependent decay, which also contributes to tumor suppression by degrading specific microRNAs that repress apoptosis and mRNA of genes that regulate lipid metabolism.3 Specific inhibition of IRE1α RNase activity or its loss leads to accumulation of dsRNA, which enhances NLRP3 inflammasome activation-mediated ICD known as pyroptosis (Fig. 1). This evidence concerns the gene ERN1 and neoplasm.