Thus,they play an important role in the innate immune system,61,62 and TLR8 agonists have been studied for their potential role intreating cancer, asthma, viral and bacterial infections.62 We used OpenMMDL to simulateand analyze the structure of a TLR8 agonist C09 (PDB ID: 3W3J).63 The gene discussed is TLR8; the disease is bacterial infectious disease.