Additionally, the presence of some high-risk genetic variants associated with kidney disease have been linked with recent African ancestry (eg, apolipoprotein L1).57 58 Black patients have also shown higher rates of organ damage compared with White patients in the USA,59 the accumulation of which is ultimately related to death60; however, damage could also be accrued via non-SLE or non-biological mechanisms. The gene discussed is APOL1; the disease is systemic lupus erythematosus.