INS and Hypoglycemia: Furthermore, the association between intensive insulin management and weight gain has been supported by many [17–19,41–44], but not all [9,28,36,38–40,45,46], prior studies, including the sentinel DCCT [17–19,41,42], performed in an era prior to availability of more physiologic insulin analogs that have been associated with reduced occurrence of hypoglycemia [20].