,40,54,57 This view is also in line with previous reports that have found that long-term supplementation with the mitochondria-targeted antioxidants mitoquinone and SS-31 failed to rescue sarcopenia in rodents,58,59 while mice deficient for Manganese SuperOxide dismutase (MnSOD), an antioxidant enzyme located in the mitochondrial matrix, do not develop muscle atrophy with aging.60 This evidence concerns the gene SOD2 and sarcopenia.