In particular, canonical Wnt genes such as WNT3, TCF7, and TCF3 were upregulated over time and positively correlated with NE or MCC markers, whereas noncanonical Wnt genes like WNT5A and WNT16 showed strong negative correlation with MCC markers (Supplemental Figure 5B). The gene discussed is TCF7; the disease is Merkel cell skin cancer.