In particular, canonical Wnt genes such as WNT3, TCF7, and TCF3 were upregulated over time and positively correlated with NE or MCC markers, whereas noncanonical Wnt genes like WNT5A and WNT16 showed strong negative correlation with MCC markers (Supplemental Figure 5B). This evidence concerns the gene WNT5A and Merkel cell skin cancer.