TRAF3 and central nervous system cancer: Interestingly, pan-cancer survival analysis demonstrated that glioma was the only cancer type in which TRAF3 levels negatively correlated with patient survival (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI178550DS1), highlighting the distinctive role of TRAF3 in glioma compared with other tumor types.