MKI67 and glioblastoma: In the mouse GBM tissues, ECH1 depletion was associated with a notable decline in Ki-67 expression compared with the control group, accompanied by elevated levels of 8-oxoG, 4-hydroxynonenal (4-HNE), and β-gal staining, which are indicative of oxidative DNA, lipid damage, and cellular senescence, respectively (Figure 6J and Supplemental Figure 6G).