Notably, the proportion of GZMB+ cells in the CD8+ T cell population was not obviously altered between the control and oeTRAF3 groups (Supplemental Figure 8, D and E), suggesting that TRAF3 overexpression in GBM cells did not affect the cytotoxicity of CD8+ T cells, but instead affected the susceptibility of tumor cells to T cells. The gene discussed is CD8A; the disease is glioblastoma.