Notably, despite the established role of TRAF3 as an inhibitor of the NF-κB pathway in glioma, restoration of the alternative NF-κB pathway by expression of MAP3K14 did not rescue the effect of TRAF3 overexpression on the oxidation capacity of GBM cells (Supplemental Figure 7, D–G). Here, NFKB1 is linked to central nervous system cancer.