TRAF3 and glioblastoma: Consistent with the results of transcriptome sequencing, we found that TRAF3 overexpression led to a significant increase in senescent cells and in the growth arrest of GBM cells, both of which were reversed by the addition of exogenous glutathione ethyl ester (GSH-EE) (Figure 2, I and J, and Supplemental Figure 2, E and F).