We found that TRAF3 overexpression substantially suppressed GBM tumorigenicity in vivo and prolonged the overall survival of mice bearing GBM0709 tumors (median survival duration of 29 days for control vs. 46 days for TRAF3-overexpressing [oeTRAF3] mice) and GBM0108 tumors (24 days vs. 40 days) (Figure 2, K and L). Here, TRAF3 is linked to glioblastoma.